Articles: Volume 23.03 July-September 2019

Making the connection between alcohol abuse and smoking

Each of 100 billion neurones in the brain connects with thousands of others.1,2 For instance, the orbitofrontal cortex (OFC), an area just above the eyes, receives inputs from our senses and the inferior temporal cortices, which help the OFC recognise objects. Inputs from the amygdala …

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Psychotic depression due to primary hyperparathyroidism

Neuropsychiatric symptoms in primary hyperparathyroidism are varied and can be easily missed, particularly in elderly population. It is believed that psychopathology emerges after a prolonged period of subclinical hypercalcaemia. This case highlights the importance of baseline tests when assessing patients presenting with mental health symptoms, …

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The use of biomarkers in Alzheimer’s disease: a case report

Uncertainties remain around the use of biomarkers in clinical practice to diagnose Alzheimer’s disease. There are several implications for both patients and clinicians, including the ethical and practical dilemmas of identifying a disease process early in its course when there are no disease-modifying treatments available.
A …

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Buprenorphine patches: impact on cognitive functions in Down’s syndrome

Opioids have been regarded as among the most effective medications for the treatment of acute, chronic severe pain and cancer pain. However, the long-term administration of opioids continues to be controversial. There are concerns surrounding misuse, abuse and addiction.1 Dr Javaid et al report of …

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Clozapine-induced hepatitis confirmed by rechallenge

Clozapine is an atypical antipsychotic that holds a unique role in the management of treatment-resistant schizophrenia. Well known side-effects include agranulocytosis and myocarditis but associated hepatic disorders are less familiar and listed under ‘rare or very rare’ by the British National Formulary.1 However, a transient …

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New unitary metrics for dementia test accuracy studies

Diagnostic test accuracy studies generally present results in terms of the sensitivity, specificity, and predictive values of the test being examined. Although these metrics are familiar, they may be difficult to interpret and apply to individual patients. This article briefly presents some new easily calculated …

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Anti-CGRP monoclonal antibodies: breakthrough in migraine therapeutics

Migraine is considered as one of the most debilitating neurological disorders but the success of the anti-calcitonin gene-related peptide (CGRP) therapies marks a new era in the treatment of migraine and has paved way for further research into the exact pathophysiology of migraine. Here, the …

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The exposome: embrace the complexity

Links between the microbiome and psychiatric and neurological disease have been the focus of much attention in recent years and may add to our understanding of the complexities of these diseases in tandem with our developing knowledge of the genome’s role. However, a third domain …

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