MBCT no better than drugs for depression…

Mindfulness-based cognitive behaviour therapy is not superior to maintenance antidepressant therapy in patients with depression, according to the UK PREVENT study (Lancet 2015;doi: http://dx.doi.org/10.1016/S0140-6736(14)62222-4).
The primary care study involving 424 patients found no difference in time to relapse or recurrence over a two-year period. No adverse …

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MS drugs found to be cost effective

Both interferon beta and glatiramer acetate are cost effective compared with non-treatment in slowing disability progression in patients with relapsing-remitting MS over a six-year period, an analysis of the NHS risk-sharing scheme has shown (Lancet Neurology 2015; doi: http://dx.doi.org/10.1016/S1474-4422(15)00018-6).
Progression rates were 60–75% of those in …

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Fingolimod effective over four years

The effectiveness of fingolimod is maintained for four years in patients with relapsing-remitting MS, an extension to the FREEDOMS trial has shown (Neurology 2015;84:1582-91).
Compared with placebo, fingolimod reduced annualised relapse rate, brain volume loss and confirmed disability progression and no new safety signals were reported.

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Brexpiprazole in schizophrenia

Brexpiprazole – considered to be a successor to the structurally related aripiprazole – has been shown to reduce PANSS score and global severity scores in patients with acute schizophrenia (Am J Psychiatry 2015; http://dx.doi.org/10.1176/appi.ajp.2015.14101275).
The most frequent adverse events were akathisia (4–7% vs 2% with placebo) …

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Quetiapine’s modest effect

A reappraisal of the evidence for immediate-release (IR) quetiapine in the treatment of schizophrenia has concluded that it has only a small effect on psychotic symptoms in the first 12 weeks at the price of weight gain and sedation (Br J Psychiatry 2015;doi: 10.1192/bjp.bp.114.154377).
The meta-analysis …

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Donepezil in people with brain tumour

Donepezil has a modest effect on cognitive function in people with neurotoxicity secondary to radiotherapy for a brain tumour (J Clin Oncol 2015;doi: 10.1200/JCO.2014.58.4508).
Of 198 adults surviving for more than six months, 24 weeks of treatment with donepezil improved scores for memory and motor speed …

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Cholinesterase inhibitor efficacy unclear in neurological conditions

A Cochrane review has found that the evidence is inconclusive for the efficacy of cholinesterase inhibitors in patients with cognitive impairment or dementia associated with neurological conditions (Cochrane Database Syst Rev 2015 Mar 3;3:CD009444. doi: 10.1002/14651858.CD009444.pub3).
The review included eight trials involving a total of 567 …

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