Isradipine for Parkinson’s disease

To date, no treatment has been shown to delay progression of Parkinson’s disease (PD) but there is evidence that calcium channel blockers (CCBs) are associated with a lower risk of PD. For example, one meta-analysis found that CCBs were associated with a reduction in PD …

More details...

Study assesses cancer risk with MS therapies

A data-linkage study from Sweden has assessed the risk of cancer in people with multiple sclerosis after starting treatment with fingolimod, natalizumab or rituximab.
Combining data from the Swedish MS register, the Swedish Cancer Register and other national health care and census registers, the study included …

More details...

Antipsychotic for schizophrenia without metabolic effects?

Lumateperone is (like haloperidol) a butyrophenone antipsychotic. Its pharmacology is complex, with activity on multiple neurotransmitters resulting in modulation of serotonin, dopamine and glutamate function. It may also lack the adverse metabolic effects of other antipsychotics. It is orally active and taken once daily.
Lumateperone was …

More details...

Worse seizure control after valproate stopped

Seizure control deteriorates in many women after discontinuing valproate, a UK analysis shows.
The survey of 215 specialist valproate prescribers included experience from 4,775 patient encounters. After reviewing the need for treatment with valproate, most patients continued treatment with valproate. Among respondents who switched patients to …

More details...

Little evidence for prophylaxis of migraine in children

There is no evidence of efficacy for long term prophylaxis of migraine in children, according to a new systematic review and network analysis.
The analysis, by researchers from Germany, the UK, the US and Switzerland, included 23 studies involving a total of 2,217 children who received …

More details...

Evidence lacking for drug treatment of cannabis use disorder

There is an urgent need for an effective treatment strategy for cannabis use disorder because recreational use is becoming common in the general population, say US specialists.
Cannabis use disorder is defined (in DSM-5) as chronic use associated with abuse and dependence featuring problematic use, craving, …

More details...

Mental health in the time of CoVid-19

The charity Mind has voiced its concern about the broad scope of legislation introduced by the Government as part of its strategy to tackle the CoVid-19 crisis.
The measures could ‘severely impact the rights of people with mental health problems detained for hospital treatment’, Mind believes, …

More details...

Audit finds no hazardous prescribing for people with dementia

There is ‘no evidence of hazardous prescriptions regarding dosages and interactions of psychotropic medications’ in the National Audit of Dementia.
Commissioned by the Healthcare Quality Improvement Partnership, the audit reviewed the quality of prescribing in 2,702 prescriptions from the records of 1,575 people with dementia (mean …

More details...

Newer AEDs not more tolerable than older agents

‘Efficacy and tolerability are two sides of the same coin in achieving successful epilepsy treatment’, say the authors of a 30-year longitudinal study in Scotland.
The study monitored a cohort of 1,795 people (median age 33) with newly diagnosed and treated epilepsy attending a single specialist …

More details...

Grant helps DECODE dementia assessment

The University of Exeter has received grants totalling £73,000 to support the further development of software to refine the assessment of people with dementia.
DECODE (DEmentia identification COmputerized DEcision support system, https://www.decodedementia.com) is ‘an intelligent, evidence-based computerised decision support system for dementia identification’ developed in collaboration …

More details...

Web design and marketing agency Leamington Spa