Cognitive screeners for MCI: is correction of skewed data necessary?

Correct identification of mild cognitive impairment (MCI) may provide the opportunity for intervention with diseasemodifying therapeutics. Pending the development of widely applicable diagnostic biomarkers, use of cognitive screening instruments (CSIs) as part of clinical assessment may represent the best method for early MCI diagnosis. However, skewing of CSI test scores may jeopardise test utility. Here, Dr Larner examines various short CSIs in a secondary care setting to assess whether or not the assumption of normality is valid.

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